THE NAMES OF MEDICATIONS

David Placek, recently featured on “Sunday Morning” on CBS, is a professional namer who is paid as much as $100,000 to name a new product. His company, Lexicon, is responsible for brand names such as Swiffer, Dasani, OnStar, Outback, for Subaru, and Pentium, for Intel. And Placek says that despite the impression one might get from “Mad Men,” it’s not as easy to name a new product as it appears.

However, tricky as naming mass market products might be, it is easier and less fraught with pitfalls than naming medications, which rather than being in the hands of companies such as Lexicon, is under the watchful eye of an organization called the United States Adopted Names Council.

While watching the evening news my husband and I often react with dismay at the parade of commercials, mostly for medications, wondering how in the world the manufacturers come up with brand names such as Latuda and Farxiga, Zaditor and Anoro, Prevnar and – heaven help us – Harvoni.

A prescription medication must have a generic name, for example omeprazole, and a brand name, which we know as Prilosec. This naming is a complicated process because there are so many combinations of words and letters that might make sense to you or me but that won’t pass muster in the world of pharmaceuticals.

For one thing, they have to be recognizable all over the world, not just in the United States. Certain letters or sets of letters, me, str, x, and z, aren't allowed at the beginning of a generic name. And the letters h, j, k and w can’t be used because they lead to pronunciation problems in other languages. Plus there are occasionally suggested combinations that might sound fine to our ears but have negative or even obscene connotations elsewhere.

Prefixes that imply better, newer, or more effective as well as those that evoke the name of the sponsor, dosage form, duration of action or rate of drug release should not be used. And prefixes that have an anatomical connotation or refer to a medical condition are not acceptable.

Of course there are many drugs, such as Xalkori, used to treat lung cancer, which don’t have to resonate with consumers because they won’t be buying them at their local pharmacy. Xalkori was named by the full-service branding consultancy InterbrandHealth, which also came up with such tongue-twisters as Zelboraf, Yondelis, and Horizant. It’s doubtful you’ve heard of those, but you have heard of the Interbrand-named medications Prozac and Viagra.

In addition to the Adopted Names Council, drug names have to pass muster with the U. S. Food and Drug Administration and its European counterpart, the European Medicines Agency. Strange as it may seem, a drug cannot boast about a drug’s power or efficacy, which is why, according to David Schultz at Slate, “You won’t be seeing any drugs named Cholesterol Busters or Angina-B-Gone.”

Care has to be taken to prevent one drug being confused with another, which could be the case with Neulasta, an immune system booster following chemotherapy, and Lunesta, which is a sleeping pill. Mixing up those two could have dire consequences.

Even over-the-counter drug names can be puzzling. The function of many of them is obvious but not always. We don’t have to wonder what Nyquil and TheraFlu are to be used for, but Zyrtec and Zegerid could have you scratching your head.

All of the drugs we are likely to pick up at a pharmacy, as peculiar as their brand names might be, have chemical names that are even stranger. The chemical name for Celebrex is roficoxib. For Viagra it’s sildenafil. Those unwieldy names describe the drugs’ chemical components and fall into categories such as statins, used to lower cholesterol, and benzodiazepines, for treating anxiety. Occasionally a drug is named for the individuals who developed it. Carfilzomib, used to treat multiple myeloma, was named for molecular biologists Philip Whitcome and his wife, Carla.

Keeping all of this in mind, I’m sure you’ll agree, when you’re filling out forms for that new doctor, that no matter how odd the name of your medication might seem, it’ll be easier to list Victoza, Invokana or Jublia rather than liraglutide, canagliflozin, or efinaconazole, names better limited to the laboratory or the pharmacist’s glossary.

Posted on Thursday, May 28, 2015 at 8:19AM by Registered CommenterPatricia P. Jennings | CommentsPost a Comment

THE REINCARNATION OF IGNATIUS J. REILLY

Back in the early eighties my husband read a book about which he was enthusiastic although his enthusiasm didn’t impel me to pick it up and read it. He had his books. I had mine.

A few weeks ago, for reasons known only to the gods, I stumbled upon the book online and downloaded it onto my iPad. And I’m delighted that the gods brought it back into my line of vision.

A Confederacy of Dunces by John Kennedy Toole won the Pulitzer Prize for fiction in 1981. The award was posthumous. Toole had committed suicide in 1969, at age thirty-one, eleven years before the book’s publication, ostensibly because he could not find a publisher.

Humans deal with rejection in a variety of ways, and who knows what other factors might have contributed to Mr. Toole’s doing away with himself. We’ll never know for sure. His mother destroyed his suicide note.

If the lack of a publisher is the reason, much of the blame has been laid at the feet of Robert Gottlieb, editor at the time at Simon and Schuster who wasn''t satisfied with Toole’s original manuscript. And although Toole made many revisions over a two year period, Gottlieb ultimately rejected the novel saying:

“The book is a brilliant exercise in invention, but it isn't really about anything. And that's something no one can do anything about.” I can’t imagine what Mr. Gottlieb could have been driving at. Whatever it was, no matter how much Toole tinkered with it, Gottlieb eventually suggested that Toole move on to writing something else.

As far as I know Gottlieb is still living, and I have to wonder if he felt any responsibility for Toole’s descent into hopelessness. Probably not. The world of publishing is a killer of dreams that only the strongest survive.

A Confederacy of Dunces, described as “a canonical work of modern literature of the Southern United States,” is the story of Ignatius J. Reilly, a character unlike any you are apt to encounter elsewhere. He is morbidly obese. He lives with his mother in New Orleans. He is plagued by attacks of flatulence, and he is utterly contemptuous of the mores of contemporary society.

He has been resting in peace for thirty years until coming back to life recently with a resurgence of interest in his adventures and in the life of his creator. Audiobooks.com recently recommended A Confederacy of Dunces, and a definitive book, Butterfly in the Typewriter:  The Tragic Life of John Kennedy Toole and the Remarkable Story of A Confederacy of Dunces, by Cory MacLauchlin, reveals so many interesting details about the provenance of the book that I’m planning to read it again.

A Confederacy of Dunces is not for everyone. I found it fascinating and amusing, although some with delicate sensibilities might find it unappetizing. If you’ve visited New Orleans you will agree that the book captures the mood of that unusual city. MacLauchlin writes: “As many New Orleanians attest, no other writer has captured the essence of the city more accurately than Toole.” And underscoring that tribute is a statue of Ignatius J. Reilly standing outside the old D. H. Holmes department store, and other characters from the book make annual Mardi Gras appearances.

Credit for the publication goes primarily to Toole’s mother who was determined that her genius son’s work would be published. After it was rejected by numerous major publishers, she prevailed upon Walker Percy, author and instructor at Loyola University New Orleans, demanding that he read it. He initially resisted but as he recounts in the book's foreword:

“The lady was persistent. There was no getting out of it. Only one hope remained – that I could read a few pages and that they would be bad enough for me to read no farther. But in this case I read on. And on. First with the sinking feeling that it was not bad enough to quit, then with a prickle of interest, then a growing excitement, and finally incredulity: surely it was not possible that it was so good.”

Things moved quickly after that. The book was published by the Louisiana State University Press in 1980 and a year later won the Pulitzer Prize for Fiction, only the second to be awarded posthumously.* It has since been translated into twenty-two languages.

I have long been fascinated by stories of rejection that have a happy ending. Toole the man did not have a happy ending. But he would be more surprised than anyone that so long after his demise his rejected book is not only still being read, but is now considered a classic, and that there is a recent upsurge of interest in his work and his life.

Incidentally, the book's title refers to an epigraph from Jonathan Swift's essay Thoughts on Various Subjects, Moral and Diverting: "When a true genius appears in the world, you may know him by this sign, that the dunces are all in confederacy against him" – as appropriate to Toole as to Ignatius J. Reilly.

 

*James Agee's A Death in the Family was awarded the prize in 1958.

Posted on Monday, May 4, 2015 at 9:25AM by Registered CommenterPatricia P. Jennings | CommentsPost a Comment

FINANCIAL SECURITY

I recently read the biography of a gentleman who, although he was a professional musician, a bass player in the Denver Symphony, worked for a number of years to make ends meet as a skycap at the Denver airport in the late 40s, before the orchestra had a year-round season, as was true of most American orchestras.

One day he stumbled upon an idea: He and his fellow skycaps could form a kind of investment club in order to get a financial foothold. “We set up a corporation,” he says, “the whole legal thing with lawyers, and got it set up right.”

The plan was for each member to put five dollars a week into the fund and at the end of the year the money would be invested in stock market mutual funds. There were forty men, and at five dollars a week, that $800 a month would yield a sizable chunk to invest by year’s end.

But the men grew nervous and started pulling their money out saying, “I need money I can spend, and now.” They didn’t understand what this small investment could mean in terms of growing their money. So they all took out their money except the gentleman himself who, in a few years, had accumulated nearly ten thousand dollars. The men accused him of cheating them. But he admonished them, “You cheated yourselves.”

In the early 1950s, my father, whose employer did not have a pension plan, was advised by a knowledgeable friend to invest in mutual funds, which although they had been around for a while, weathering the Depression and World War II, were still considered pretty exotic in the 50s.

My father not only heeded the gentleman’s advice putting a portion of his income into mutual funds, he also attempted to convince others to do the same. It wasn’t an easy sell because people were skeptical. They would rather keep their money in passbook savings accounts or in a shoebox under the bed.

At the same time my father enrolled me into a mutual fund placing some of my earnings from playing the piano in church and babysitting into the fund each month. When I was twenty-one the down payment on my first grand piano came from my mutual funds earnings. And without the money my parents had squirreled away into mutual funds, rather than live out their lives in relative comfort, they would have had to rely largely on Social Security. I shudder to think of how different their life would have been.

Mutual funds are safe investments because, rather than putting one’s eggs into a single basket, as is the case with individual stocks, the money is invested in a variety of funds. Most of us are familiar with them by now because company retirement plans such as 401 K’s and Roth IRAs are based on money invested in mutual funds.

Microsoft recently published an online list titled “Four Ways to Earn Money Without Lifting a Finger.” At the top of this list are mutual funds: “Investing can multiply your money for decades if you play your cards right. You have probably heard of compounding interest, when your money makes money and then that money makes money. This is what happens when you set aside money in something like a 401(k) account and leave it there until retirement. Once you put the money in, you don't have to do anything, and you're still making money. All you have to do is review your statements every so often to make sure your investments are meeting your needs and goals.”

Another of their suggestions is real estate. That might work for some but it sounds like work to me.

The easiest way to save money is to pay yourself first. If you’re doubtful you can spare enough to invest in a mutual fund, put five or ten dollars a week into a targeted savings account. You won’t miss it, and the way time flies it won’t be long until you have enough to open a mutual fund account, which might not require as much as you think. A mutual fund can be opened with as little as $500, or less if you meet certain requirements such as having a set amount automatically taken from your bank account each month. And explore no load funds so that you don’t have to fork over a chunk of your money to an intermediary – a broker or financial planner.

For a wage earner just starting out, putting aside a small amount each month can grow in ways that will surprise and delight down the road. And for those of you with expanding families, wouldn’t opening a mutual fund for that new grandchild be a fantastic way to put the child on the road to financial security?

Your earnings from mutual funds and other conservative investments might not move you from the ninety-nine per cent to the one per cent, but when it’s time to put four new tires on your car or get your winter-ravaged driveway repaired you should be able to do so without having to take out a loan.

Posted on Sunday, April 12, 2015 at 10:26AM by Registered CommenterPatricia P. Jennings | CommentsPost a Comment

BINGE WATCHING

Thanks to TiVo and other digital recording devices, video streaming, and other new media, a phenomenon is taking place among America’s televiewers that couldn’t have happened before TiVo came into being, in 1999 – binge watching. Never before have we been able to watch every episode of our favorite show in one sitting – if we’re so inclined and our gluteus maximus doesn’t protest too loudly.

And with multiple cable channels stacked on top of the Big Three networks of our youth, there’s an endless supply of quality series on which to binge. For some it’s Netflix’s “House of Cards” or “Orange Is the New Black.” For others AMC’s “Breaking Bad,” and “Sons of Anarchy” from FX. And the list goes on.

My husband and I didn’t watch original non-network shows such as “The Sopranos” and “Sex and the City” because we got so tired of hearing about them we decided just to ignore them.  Annoying contrarians that we are, we didn’t wish to participate in the Monday morning water cooler rehash.

Our first foray into multiple-episode watching were several seasons of “The New Adventures of Old Christine,” starring Julia Louis-Dreyfus. We hadn’t been regular watchers of “Seinfeld, where Louis-Dreyfus initially gained fame, so it wasn’t until we had a couple of seasons of “Christine” under our belt that we came to appreciate what a comic genius the lady is, sort of a Lucy brought up to date.

Since then we’ve gotten aboard the “Seinfeld” bandwagon. A few months ago a friend suggested that we watch an episode she found especially amusing. It was so hilarious that we have since watched a majority of the 180 episodes, usually two at a time, which may not qualify as genuine binge watching, but we know that two more recorded episodes will be waiting for us the next evening. 

The closest we’ve come to bona fide binge watching is a gritty, French police drama you’ve probably never heard of called “Spiral.”  Recommended by a French friend, “Spiral” is a periodically gory police/courthouse drama, not so different from “Law and Order” or other domestic whodunits. But perhaps, because it’s all transpiring in French (with subtitles), it exudes a frisson of Gallic sophistication that tempers the gore. Plus, the police captain is a plucky young woman who is, of course, smarter than all the men and a voluptuous red-headed prosecutor whose attributes keep my husband alert. We have streamed forty-two episodes (Netflix), five seasons, and are eagerly awaiting a sixth season.

Another winner from across the pond is the Danish series “Borgen,” on DVD. The leading character is a forty-ish mother of two who has been elected Prime Minister of Denmark. Her effort to satisfy her constituents and grapple with her detractors, while trying to keep her husband and children from feeling abandoned, is a challenge. Highly praised by viewers for its acting, writing, settings and realism, this is one foreign entry whose subtitles are excellent. You can actually read them without squinting or using binoculars.

A few years back while flipping through Netflix for something interesting to watch I stumbled upon a five-star show we’d never even heard of, “Doc Martin,” which a year or so later made its way onto WQED’s Saturday even Britcom block. We enjoyed several seasons in the fictional village of Portwenn observing the curmudgeonly doctor, who had developed hemophobia, fear of blood, abandoned his big-city surgical practice, and come to Portwenn to treat, with a complete lack of grace, the townfolk who were caught off guard by his chilliness. He even hates dogs.

And although watching weekly episodes of PBS’s “As Time Goes By” doesn’t qualify as binge watching, by now we’ve watched every episode so often that we’ve watched Lionel and Jean grow old over and over and over again.

It’s too soon to start binge watching “Mad Men,” or “Downton Abbey,” but it’s easy to imagine, a few years down the road, when those actors have long gone on to other pursuits, plenty of us will be popping corn and plopping down for hours at a time, immersed in the goings-on with Lord Grantham and his mischievous charges at Highclere Castle or Don Draper and the smoking, boozing admongers at Sterling Cooper.

Posted on Thursday, March 19, 2015 at 8:26PM by Registered CommenterPatricia P. Jennings | CommentsPost a Comment

NON-FICTION...OR NEARLY

Belonging to a book club is a splendid way to increase one’s reading, meet new people – and, if we’re not careful, add inches to the waistline.  I hosted our community’s monthly gathering recently. Reading the book was the easy part. Deciding what to serve was the challenge.

Some interesting books have graced our annual lists, but in my opinion a few might just as easily have been passed over. Because most of the women are wives and mothers, a majority of the books are what I would describe as domestic novels, Gone Girl by Gillian Flynn being a good example. It wasn’t quite my cup of tea, but the fact that it has been made into a major motion picture proves that it hit its target with readers. And at least one from the 2015 list, Big Little Lies, has been optioned for a TV movie starring Nicole Kidman and Reese Witherspoon. 

In between book club assignments, I sandwich in books, often non-fiction, that probably wouldn't make the book club cut because of length, subject matter, or because there just isn’t time to read everything.

Most of us who are old enough remember where we were when John F. Kennedy was shot and what we were doing at 8:45 a.m. on September 11, 2001. And we might remember where we were when thirty-three Chilean miners who had been trapped underground from August 5th to October 13th, 2010 were rescued, one by one, on live television, to worldwide rejoicing.

  • In Deep Down Dark (2014) Héctor Tobar describes in gripping detail the ordeal of thirty-three men trapped three miles underground for sixty-nine days in the Copiapó copper-gold mine northern Chile with little food, little water and even less hope. He recounts not only their terrifying ordeal, the helplessness of their loved ones, but the herculean efforts waged to rescue them. Mammoth drilling equipment was brought from around the world, including a Schramm rotary drill from West Chester, Pennsylvania.

The miracle that not one miner was lost demonstrates the power of the men's solidarity and attests to the fact that we don't know what physical and mental privates we can bear until we are tested.                                    

  • For those of you who are fascinated by things culinary and also like a good yarn, you will enjoy The Sharper Your Knife the Less You Cry (2007) by Kathleen Flinn. Although Flinn is a journalist who has written for a long list of publications, her true love is cooking. In The Sharper Your Knife the Less You Cry, she describes the rigors of earning her diploma from the world famous Cordon Bleu cooking school in Paris.

This true story earned her the 2012 award for Best Book in the Non-Fiction Autobiography/Memoir category from the American Society of Journalists and Authors. The beauty of Flinn’s writing is its accessibility and the way she is able to weave her real life into the story of her journey from adequate cook to master chef.  And there is a sprinkling of delectable-sounding recipes that sound doable, even by me.                                        

  • Although as a classical musician I’ve helped provide much music for ballet, I’ve never had a depth of understanding of the art. But that changed somewhat when I read Misty Copeland’s Life in Motion: An Unlikely Ballerina (2014). Recently profiled on CBS “Sunday Morning,” Misty Copeland is a principal soloist with the American Ballet Theater, which has been designated by Congress as America’s National Ballet company just as the Bolshoi is Russia’s ballet company.

And by the way: Misty Copeland happens to be African American, and although her ascent to stardom contains many stereotypical elements of childhood deprivation, her rise was especially challenging as she and her four siblings, each by a different father, were raised by a beautiful but unstable mother who would pick up and drag the family to a new town at the drop of a hat.

That Misty was able to pursue her dream and reach the pinnacle of classical dance – despite the turmoil swirling around her – in a world where ballerinas are supposed to be fair of hair and fair of skin, is nothing short of miraculous.                             

  • Otto and Elise Hampel, a working class couple in Berlin, were not much interested in politics until Elise learned that her brother had fallen to the Nazis in France. It was then that she and her husband began committing acts of civil disobedience. Every Man Dies Alone (1947), by Hans Fallada, is a fictionalized account of their story based on their Gestapo files.

When a friend mentioned she was reading a book that involved Nazis, my reaction was that I’m just about “up to here” with tales of Nazi cruelty. But there was something in her description that impelled me to read the Kindle sample and eventually the entire book.

Not translated into English until 2009, Every Man Dies Alone, which the author wrote in twenty-three days, became a surprise best seller in the UK and the US and was described by the famed writer, chemist and Holocaust survivor Primo Levi as “a phenomenon,” and "the greatest book ever written about German resistance to the Nazis."

It is a fascinating and sobering read.

Posted on Wednesday, February 25, 2015 at 8:01AM by Registered CommenterPatricia P. Jennings | Comments2 Comments | References1 Reference
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